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RT Journal Article
SR Electronic
T1 Gross-total Surgery of Supratentorial Low-grade Gliomas under Intraoperative MR Guidance
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 89
OP 98
VO 22
IS 1
A1 Schneider, Jens P.
A1 Schulz, Thomas
A1 Schmidt, Frank
A1 Dietrich, Jürgen
A1 Lieberenz, Siegbert
A1 Trantakis, Christos
A1 Seifert, Volker
A1 Kellermann, Steffen
A1 Schober, Ralf
A1 Schaffranietz, Lutz
A1 Laufer, Mario
A1 Kahn, Thomas
YR 2001
UL http://www.ajnr.org/content/22/1/89.abstract
AB BACKGROUND AND PURPOSE: Length of survival of patients with low-grade glioma correlates with the extent of tumor resection. These tumors, however, are difficult to distinguish intraoperatively from normal brain tissue, often leading to incomplete resection. Our goal was to evaluate the effectiveness of intraoperative MR guidance in achieving gross-total resection.METHODS: We studied 12 patients with low-grade glioma who underwent surgery within a vertically open 0.5-T MR system. During surgery, localization of residual tumor tissue was guided by interactive, near real-time imaging. The amount of residual tumor tissue on MR images was evaluated at the point of the operation at which the neurosurgeon would have terminated the procedure under conventional conditions (first control) and again before closing the craniotomy.RESULTS: Significant residual tumor (more than 10% of original tumor volume) was shown in eight patients at the first control condition. The percentage of resection varied from 26% to 100% (mean, 68%) at this time. Twelve tissue samples from seven patients were obtained in areas identified as residual tumor on MR images. In 10 cases, the neuropathologic investigation confirmed the presence of residual low-grade glioma; in two cases, the borderzone of tumor was identified. In evaluating the final sets of images, we found total resection in six cases, over 90% resection in five cases, and 85% resection in one case (mean, 96%).CONCLUSION: Surgical treatment of low-grade gliomas under intraoperative MR guidance provides improved resection results with maximal patient safety.