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PT  - JOURNAL ARTICLE
AU  - Bizzi, Alberto
AU  - Uluğ, Aziz M.
AU  - Crawford, Thomas O.
AU  - Passe, Ted
AU  - Bugiani, Marianna
AU  - Bryan, R. Nick
AU  - Barker, Peter B.
TI  - Quantitative Proton MR Spectroscopic Imaging in Acute Disseminated Encephalomyelitis
DP  - 2001 Jun 01
TA  - American Journal of Neuroradiology
PG  - 1125--1130
VI  - 22
IP  - 6
4099  - http://www.ajnr.org/content/22/6/1125.short
4100  - http://www.ajnr.org/content/22/6/1125.full
SO  - Am. J. Neuroradiol.2001 Jun 01; 22
AB  - Summary: Serial MR imaging and quantitative proton MR spectroscopic imaging (MRSI) findings of a 4-year-old boy with acute disseminated encephalomyelitis (ADEM) are reported. Over a 2-month period characterized by an initial illness and two relapses, each with full recovery, MR imaging exhibited the appearance and disappearance of multifocal lesions throughout the CNS that correlated only partly with the neurologic impairment. During one relapse, MRSI revealed low levels of N-acetylaspartate (NAA) within the regions of prolonged T2 signal intensity. All other metabolites were normal. At follow-up, the MR imaging and MRSI abnormalities had fully resolved. MRSI might play an important role in the diagnosis of ADEM, as well as in the elucidation of underlying pathophysiologic processes in this poorly defined disorder of children. This case demonstrates that reduced levels of NAA are not always associated with neuronal loss, irreversible tissue damage, or poor neurologic outcome.