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PT  - JOURNAL ARTICLE
AU  - Li, Li Min
AU  - Narayanan, Sridar
AU  - Pike, Gilbert Bruce
AU  - Andermann, Frederick
AU  - Dubeau, François
AU  - Arnold, Douglas L.
TI  - Magnetization Transfer Ratio Is Unable to Lateralize Epileptic Foci in Patients with Temporal Lobe Epilepsy
DP  - 2000 Nov 01
TA  - American Journal of Neuroradiology
PG  - 1853--1856
VI  - 21
IP  - 10
4099  - http://www.ajnr.org/content/21/10/1853.short
4100  - http://www.ajnr.org/content/21/10/1853.full
SO  - Am. J. Neuroradiol.2000 Nov 01; 21
AB  - BACKGROUND AND PURPOSE: A preliminary report suggested that magnetization transfer ratio (MTR) was useful to lateralize epileptic foci in patients with refractory temporal lobe epilepsy (TLE). We attempted to confirm this finding in a larger group by investigating the relationship between MTR of mesial temporal structures and seizure lateralization in patients with refractory TLE.METHODS: We compared the MTR of amygdalae and hippocampi of 10 patients with unilateral TLE to values obtained from 10 healthy control participants.RESULTS: Three of 10 patients with TLE had MTR values that were 2 SD below the normal mean; the MTR abnormality was concordant with electroclinical lateralization in only one of the three.CONCLUSION: We conclude that MTR measurements of amygdalae and hippocampi are not useful for lateralization of TLE.