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PT  - JOURNAL ARTICLE
AU  - Sorteberg, Angelika
AU  - Sorteberg, Wilhelm
AU  - Turk, Aquilla S.
AU  - Rappe, Alan
AU  - Nakstad, Per Hj
AU  - Strother, Charles M.
TI  - Effect of Guglielmi Detachable Coil Placement on Intraaneurysmal Pressure: Experimental Study in Canines
DP  - 2001 Oct 01
TA  - American Journal of Neuroradiology
PG  - 1750--1756
VI  - 22
IP  - 9
4099  - http://www.ajnr.org/content/22/9/1750.short
4100  - http://www.ajnr.org/content/22/9/1750.full
SO  - Am. J. Neuroradiol.2001 Oct 01; 22
AB  - BACKGROUND AND PURPOSE: Treatment of ruptured aneurysms with Guglielmi detachable coils (GDCs) has been shown to prevent repeat bleeding. To assess whether GDC coiling alters aneurysmal pressure, we measured intraaneurysmal pressure in two canine types of carotid artery aneurysms before and after GDC placement.METHODS: A 0.014-inch guidewire with a pressure transducer was inserted into parent arteries and domes of surgically created aneurysms. Intravascular static pressures were recorded before and during saline power injections (10, 20, and 30 mL over 1 and 2 s), before and after GDC placement. Common femoral arterial pressure was monitored.RESULTS: Saline power injections reproducibly and abruptly increased pressure in parent arteries and aneurysms. Mean intraaneurysmal pressure varied (18 ± 4 [10 mL] to 75 ± 15 mm Hg [30 mL]), independent of injection duration. Intraaneurysmal baseline pressures were higher after GDC placement (111 ± 10 versus 93 ± 15 mm Hg; P = .05). Aneurysmal pressure increases with saline injections were slightly higher after GDC placement, which dampened intraaneurysmal pressure amplitude at baseline (26.5 ± 5.6 versus 19.6 ± 7.4 mm Hg; P = .003) and during hypertension (25.3 ± 5.4 versus 19.8 ± 7.5 mm Hg, P = .002). The pressure increase slope with saline injection was delayed with GDC placement (0.24 ± 0.1 versus 0.38 ± 0.19 s; P &amp;lt; .001).CONCLUSION: Graded saline power injections into parent arteries can rapidly increase intraaneurysmal pressure. GDC treatment did not attenuate mean intraaneurysmal pressures, but both dampened the pressure amplitude and delayed pressure increases during locally induced hypertension.