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RT Journal Article
SR Electronic
T1 Acute Encephalopathy Associated with Intravenous Immunoglobulin Therapy
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 2311
OP 2315
VO 26
IS 9
A1 Wada, Akihiko
A1 Yoshida, Rika
A1 Oda, Kazushige
A1 Fukuba, Eiji
A1 Uchida, Nobue
A1 Kitagaki, Hajime
YR 2005
UL http://www.ajnr.org/content/26/9/2311.abstract
AB Summary: Intravenous immunoglobulin therapy is useful against various immune system disorders and viral infections. It is generally safe, and serious adverse reactions are uncommon. We report a rare case of acute encephalopathy following intravenous immunoglobulin therapy for human herpes virus 6 infection in a child. MR imaging findings suggest that the dominant causative mechanism of acute encephalopathy is cytotoxic edema, and the findings indicate 2 primary mechanisms. Reversibility of the restriction of water diffusion (low apparent diffusion coefficient value) on diffusion-weighted MR imaging suggests intramyelinic edema in the myelin sheath, and an increase of glutamate and glutamine complex peak on MR spectroscopy suggests excitotoxic injury to the neurons and astrocytes.