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RT Journal Article
SR Electronic
T1 Brain Compression without Global Neuronal Loss in Meningiomas: Whole-Brain Proton MR Spectroscopy Report of 2 Cases
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 2178
OP 2182
VO 26
IS 9
A1 Cohen, Benjamin A.
A1 Knopp, Edmond A.
A1 Rusinek, Henry
A1 Liu, Songtao
A1 Gonen, Oded
YR 2005
UL http://www.ajnr.org/content/26/9/2178.abstract
AB Summary: We report the findings from whole-brain proton MR spectroscopy, quantifying the neuronal marker N-acetylaspartate (NAA), for 2 presurgical meningioma patients and 10 healthy controls. The patients’ whole-brain NAA (WBNAA) concentrations were considerably elevated (3+ SDs) compared with healthy controls when excluding the tumors from brain volume; WBNAA levels normalized following correction to approximate “preneoplastic” brain size. These results suggest global neuronal preservation in these 2 patients while their brains were compressed by large, slowly growing, extra-axial masses.