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PT  - JOURNAL ARTICLE
AU  - Barkovich, A J
AU  - Chuang, S H
TI  - Unilateral megalencephaly: correlation of MR imaging and pathologic characteristics.
DP  - 1990 May 01
TA  - American Journal of Neuroradiology
PG  - 523--531
VI  - 11
IP  - 3
4099  - http://www.ajnr.org/content/11/3/523.short
4100  - http://www.ajnr.org/content/11/3/523.full
SO  - Am. J. Neuroradiol.1990 May 01; 11
AB  - Unilateral megalencephaly is a rare and poorly understood malformation resulting in the enlargement of all or part of a cerebral hemisphere. The clinical and radiologic features of 12 patients with unilateral megalencephaly are presented; pathologic correlation was available in four. All patients had seizures and developmental delay. Two were in congestive heart failure as a result of arteriovenous shunting through the abnormal hemisphere. The affected hemispheres showed a wide spectrum of involvement. Anomalies of neuronal migration were present, and there was a roughly inverse correlation between the severity of hemispheric involvement and the magnitude of enlargement. This correlation is explained via a proposed mechanism of a mild hemispheric insult in the middle-to-late second trimester. One patient had an extremely anomalous hemisphere that did not have characteristics of a neuronal migration anomaly and may have been a hamartomatous malformation. Our correlation of the clinical, radiologic, and pathologic features of unilateral megalencephaly, together with a theory of pathogenesis, should help elucidate this rare malformation.