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PT  - JOURNAL ARTICLE
AU  - Meli, F J
AU  - Boccaleri, C A
AU  - Manzitti, J
AU  - Lylyk, P
TI  - Meningeal dissemination of retinoblastoma: CT findings in eight patients.
DP  - 1990 Sep 01
TA  - American Journal of Neuroradiology
PG  - 983--986
VI  - 11
IP  - 5
4099  - http://www.ajnr.org/content/11/5/983.short
4100  - http://www.ajnr.org/content/11/5/983.full
SO  - Am. J. Neuroradiol.1990 Sep 01; 11
AB  - Thirty-seven patients with retinoblastoma were evaluated prospectively by clinical examination, lumbar puncture, and CT. Eight (22%) of the 37 were found to have meningeal dissemination. The tumor was bilateral in three patients. Two cases showed no CT signs of local recurrence. Headache, nausea/vomiting, and restlessness were the most common symptoms. CT scans in these patients showed diffuse meningeal contrast enhancement, nodular masses, ependymal-subependymal enhancement, and ventricular dilatation. Our series of eight patients with meningeal spread illustrates a considerable range of dissemination patterns referable to retinoblastoma. One case illustrated the CT finding of multiple epidural metastases.