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PT  - JOURNAL ARTICLE
AU  - Lee, W.-W.
AU  - Kim, J.-S.
AU  - Son, K.R.
AU  - Kwon, H.-M.
TI  - Atypical Diffusion-Restricted Lesion in 5-Fluorouracil Encephalopathy
AID  - 10.3174/ajnr.A2781
DP  - 2012 Mar 08
TA  - American Journal of Neuroradiology
4099  - http://www.ajnr.org/content/early/2012/03/08/ajnr.A2781.short
4100  - http://www.ajnr.org/content/early/2012/03/08/ajnr.A2781.full
AB  - SUMMARY: Central nervous system toxicity of 5-FU could show various manifestations, such as decreased alertness, disorientation, and agitation. It is generally accepted that lesions of 5-FU encephalopathy are mainly in the deep cerebral white matter and corpus callosum on MR imaging. Here we describe a case of 5-FU encephalopathy in gastric cancer with an atypical reversible diffusion-restricted lesion on MR imaging, showing bilateral basal ganglia, thalami, and parasagittal frontal cortex involvement on diffusion and T2-weighted imaging. Abbreviations BUNblood urea nitrogenCRFchronic renal failureDPDdihydropyrimidine dehydrogenase5-FU5-fluorouracilPT/INRprothrombin time/international normalized ratio