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RT Journal Article
SR Electronic
T1 Thalamic Projection Fiber Integrity in de novo Parkinson Disease
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
DO 10.3174/ajnr.A3178
A1 Planetta, P.J.
A1 Schulze, E.T.
A1 Geary, E.K.
A1 Corcos, D.M.
A1 Goldman, J.G.
A1 Little, D.M.
A1 Vaillancourt, D.E.
YR 2012
UL http://www.ajnr.org/content/early/2012/07/05/ajnr.A3178.abstract
AB BACKGROUND AND PURPOSE: Postmortem studies of advanced PD have revealed disease-related pathology in the thalamus with an apparent predilection for specific thalamic nuclei. In the present study, we used DTI to investigate in vivo the microstructural integrity of 6 thalamic regions in de novo patients with PD relative to healthy controls. MATERIALS AND METHODS: Forty subjects (20 with early stage untreated PD and 20 age- and sex-matched controls) were studied with a high-resolution DTI protocol at 3T to investigate the integrity of thalamic nuclei projection fibers. Two blinded, independent raters drew ROIs in the following 6 thalamic regions: AN, VA, VL, DM, VPL/VPM, and PU. FA values were then calculated from the projection fibers in each region. RESULTS: FA values were reduced significantly in the fibers projecting from the AN, VA, and DM, but not the VPL/VPM and PU, in the PD group compared with the control group. In addition, there was a reduction in FA values that approached significance in the VL of patients with PD. These findings were consistent across both raters. CONCLUSIONS: The present study provides preliminary in vivo evidence of thalamic projection fiber degeneration in de novo PD and sheds light on the extent of disrupted thalamic circuitry as a result of the disease itself. Abbreviations ANanterior nucleusDMdorsomedial nucleusFAfractional anisotropyPDParkinson diseasePUpulvinarSNsubstantia nigraVAventral anterior nucleusVLventral lateral nucleusVPLventral posterior lateral nucleusVPMventral posterior medial nucleus