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PT  - JOURNAL ARTICLE
AU  - Mihara, F
AU  - Gupta, K L
AU  - Murayama, S
AU  - Lee, N
AU  - Bond, J B
AU  - Haik, B G
TI  - MR imaging of malignant uveal melanoma: role of pulse sequence and contrast agent.
DP  - 1991 Sep 01
TA  - American Journal of Neuroradiology
PG  - 991--996
VI  - 12
IP  - 5
4099  - http://www.ajnr.org/content/12/5/991.short
4100  - http://www.ajnr.org/content/12/5/991.full
SO  - Am. J. Neuroradiol.1991 Sep 01; 12
AB  - To determine the most sensitive pulse sequence and to clarify the role of each pulse sequence in the MR diagnosis of uveal malignant melanoma, noncontrast T1- and T2-weighted, and postcontrast T1-weighted, spin-echo images were compared blindly and independently by two experienced observers. Thirty uveal malignant melanomas, preselected by ophthalmoscopy and sonography for size greater than 2 mm, were examined with a 1.5-T superconducting MR unit with an orbital surface coil. Fifteen tumor studies were done after the patient was injected with gadopentetate dimeglumine. Postcontrast T1-weighted images were the most sensitive in detecting melanomas, demonstrating tumors 2 mm in height accurately on axial planes and 1.6 mm in height on combined orthogonal planes. The contrast-to-noise ratio between melanoma and vitreous fluid was greatest on postcontrast T1-weighted images (average, 72.1), followed by noncontrast T1-weighted images (average, 32.9), and then by T2-weighted images (average, -21.2). Postcontrast T1-weighted images also proved useful in differentiating melanomas from subretinal fluid collections when combined with noncontrast images. We conclude that postcontrast T1-weighted images are most helpful in detecting small uveal melanomas and in differentiating melanomas from subretinal fluid collections.