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PT  - JOURNAL ARTICLE
AU  - Escalona, P R
AU  - McDonald, W M
AU  - Doraiswamy, P M
AU  - Boyko, O B
AU  - Husain, M M
AU  - Figiel, G S
AU  - Laskowitz, D
AU  - Ellinwood, E H
AU  - Krishnan, K R
TI  - In vivo stereological assessment of human cerebellar volume: effects of gender and age.
DP  - 1991 Sep 01
TA  - American Journal of Neuroradiology
PG  - 927--929
VI  - 12
IP  - 5
4099  - http://www.ajnr.org/content/12/5/927.short
4100  - http://www.ajnr.org/content/12/5/927.full
SO  - Am. J. Neuroradiol.1991 Sep 01; 12
AB  - Intermediate T2-weighted MR images and a systematic sampling stereological method were used in 37 normal volunteers, 24 to 79 years old, to assess the effects of age and sex on cerebellar volume. Female subjects (n = 21) had significantly smaller cerebellar volumes compared with males (n = 16) of similar age (t = -3.9, p less than .0008, two-tail t test). Using straight-line, univariate regression, we determined that age was not a significant predictor of cerebellar volume (R2 = 0.07, t = -1.66, p = 0.11), whereas gender did appear to account for a significant amount of variability in cerebellar volume (R2 = 0.33, t = -4.13, p = .0002). The mean absolute cerebellar volume in this study was 112 ml (SD +/- 16) for all subjects, 104 ml (SD +/- 10) for females, and 122 ml (SD +/- 16) for males. This study demonstrates the feasibility of using MR images along with a systematic stereological method to assess in vivo human cerebellar volume, thereby providing a research tool to correlate cerebellar morphology with cognitive and neuromotor function.