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PT  - JOURNAL ARTICLE
AU  - Giacometti, A R
AU  - Joseph, G J
AU  - Peterson, J E
AU  - Davis, P C
TI  - Comparison of full- and half-dose gadolinium-DTPA: MR imaging of the normal sella.
DP  - 1993 Jan 01
TA  - American Journal of Neuroradiology
PG  - 123--127
VI  - 14
IP  - 1
4099  - http://www.ajnr.org/content/14/1/123.short
4100  - http://www.ajnr.org/content/14/1/123.full
SO  - Am. J. Neuroradiol.1993 Jan 01; 14
AB  - PURPOSE This study compares sellar intensities in 17 patients without sellar pathology using half (0.05 mmol/kg, nine patients) and full-dose (0.1 mmol/kg, eight patients) gadopentetate dimeglumine (Gd-DTPA).METHODS Sellar MR studies of eight patients who received full and nine patients who received half-dose Gd-DTPA were compared, retrospectively. Sequences included pre-, immediate, and delayed postcontrast T1-weighted coronal images (1.5 T). Intensity measurements were obtained by two observers using a uniform region of interest.RESULTS Comparison of normalized intensities revealed no significant difference between intensities obtained from immediate half- and full-dose techniques for any of the tissues examined (Student&#039;s t test, P &amp;lt; .90). Delayed scans likewise demonstrated no significant intensity differences between full- and half-dose studies.CONCLUSION Our findings suggest that a 50% reduction in dosage of Gd-DTPA for sellar MR at 1.5 T results in no significant diminution in intensity of enhancement of the pituitary gland or adjacent tissues.