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PT  - JOURNAL ARTICLE
AU  - Laissy, J P
AU  - Patrux, B
AU  - Duchateau, C
AU  - Hannequin, D
AU  - Hugonet, P
AU  - Ait-Yahia, H
AU  - Thiebot, J
TI  - Midsagittal MR measurements of the corpus callosum in healthy subjects and diseased patients: a prospective survey.
DP  - 1993 Jan 01
TA  - American Journal of Neuroradiology
PG  - 145--154
VI  - 14
IP  - 1
4099  - http://www.ajnr.org/content/14/1/145.short
4100  - http://www.ajnr.org/content/14/1/145.full
SO  - Am. J. Neuroradiol.1993 Jan 01; 14
AB  - PURPOSE To determine quantitatively a possible corpus callosum (CC) involvement in normal aging and white matter diseases.METHODS Midsagittal size and signal of CC were recorded prospectively from 243 routine MR brain examinations. A midline internal skull surface (MISS) and subcutaneous fat signal intensity were measured to calculate CC/MISS and CC/fat ratios. Four groups of subjects were studied: 124 apparently healthy subjects, 45 patients with multiple sclerosis, 13 patients with a noncerebral cancer under chemotherapy, and 37 AIDS patients.RESULTS Mean surface area of CC in controls was 6.36 cm2. It was significantly larger in men than in women (P &amp;lt; .05), but CC/MISS ratio was not. Elderly controls &amp;gt; 70 years and AIDS patients displayed significant CC atrophy, as well as multiple sclerosis subjects with long-standing disease or with a severe chronic progressive form.CONCLUSION CC substance loss identification should not be based on visual inspection or on absolute area, but by means of a CC/MISS ratio.