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RT Journal Article
SR Electronic
T1 European Multicenter Study for the Evaluation of a Dual-Layer Flow-Diverting Stent for Treatment of Wide-Neck Intracranial Aneurysms: The European Flow-Redirection Intraluminal Device Study
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 841
OP 847
DO 10.3174/ajnr.A5592
VO 39
IS 5
A1 Killer-Oberpfalzer, M.
A1 Kocer, N.
A1 Griessenauer, C.J.
A1 Janssen, H.
A1 Engelhorn, T.
A1 Holtmannspötter, M.
A1 Buhk, J.H.
A1 Finkenzeller, T.
A1 Fesl, G.
A1 Trenkler, J.
A1 Reith, W.
A1 Berlis, A.
A1 Hausegger, K.
A1 Augustin, M.
A1 Islak, C.
A1 Minnich, B.
A1 Möhlenbruch, M.
YR 2018
UL http://www.ajnr.org/content/39/5/841.abstract
AB BACKGROUND AND PURPOSE: Endoluminal reconstruction with flow-diverting stents represents a widely accepted technique for the treatment of complex intracranial aneurysms. This European registry study analyzed the initial experience of 15 neurovascular centers with the Flow-Redirection Intraluminal Device (FRED) system.MATERIALS AND METHODS: Consecutive patients with intracranial aneurysms treated with the FRED between February 2012 and March 2015 were retrospectively reviewed. Complications and adverse events, transient and permanent morbidity, mortality, and occlusion rates were evaluated.RESULTS: During the defined study period, 579 aneurysms in 531 patients (median age, 54 years; range, 13–86 years) were treated with the FRED. Seven percent of patients were treated in the acute phase (≤3 days) of aneurysm rupture. The median aneurysm size was 7.6 mm (range, 1–36.6 mm), and the median neck size 4.5 mm (range, 1–30 mm). Angiographic follow-up of &gt;3 months was available for 516 (89.1%) aneurysms. There was progressive occlusion witnessed with time, with complete occlusion in 18 (20%) aneurysms followed for up to 90 ± 14 days, 141 (82.5%) for 180 ± 20 days, 116 (91.3%) for 1 year ± 24 days, and 122 (95.3%) aneurysms followed for &gt;1 year. Transient and permanent morbidity occurred in 3.2% and 0.8% of procedures, respectively. The overall mortality rate was 1.5%.CONCLUSIONS: This retrospective study in real-world patients demonstrated the safety and efficacy of the FRED for the treatment of intracranial aneurysms. In most cases, treatment with a single FRED resulted in complete angiographic occlusion at 1 year.ASPIReAneurysm Study of Pipeline in an Observational RegistryEuFREDEuropean Flow-Redirection Intraluminal Device StudyFREDFlow-Redirection Intraluminal DevicePUFSPipeline for Uncoilable or Failed Aneurysms Study