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PT  - JOURNAL ARTICLE
AU  - Leinsinger, G
AU  - Piepgras, A
AU  - Einhäupl, K
AU  - Schmiedek, P
AU  - Kirsch, C M
TI  - Normal values of cerebrovascular reserve capacity after stimulation with acetazolamide measured by xenon 133 single-photon emission CT.
DP  - 1994 Aug 01
TA  - American Journal of Neuroradiology
PG  - 1327--1332
VI  - 15
IP  - 7
4099  - http://www.ajnr.org/content/15/7/1327.short
4100  - http://www.ajnr.org/content/15/7/1327.full
SO  - Am. J. Neuroradiol.1994 Aug 01; 15
AB  - PURPOSE To determine whether a standardized stimulation challenge with acetazolamide will be helpful for assessing the vasodilatory capacity in patients with obstructive cerebrovascular disease. METHODS To establish normative data of the cerebrovascular reserve capacity, a group of 41 control patients was investigated. The regional cerebral blood flow was measured quantitatively before and after stimulation with acetazolamide using the xenon 133 inhalation method and dynamic single-photon emission CT. RESULTS A significant increase of regional cerebral blood flow was found after administration of 1 g of acetazolamide. By doubling the dose no significant further increase was measured. We found no correlation of either baseline or stimulated flow values with age. However, a linear dependence between the stimulated flow values and their respective baseline values was observed. CONCLUSION The standardized challenge with acetazolamide seems to be a reliable method to determine cerebrovascular reserve capacity quantitatively.