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RT Journal Article
SR Electronic
T1 Volumetric MRI Study of the Brain in Fetuses with Intrauterine Cytomegalovirus Infection and Its Correlation to Neurodevelopmental Outcome
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 353
OP 358
DO 10.3174/ajnr.A5948
VO 40
IS 2
A1 Grinberg, A.
A1 Katorza, E.
A1 Hoffman, D.
A1 Ber, R.
A1 Mayer, A.
A1 Lipitz, S.
YR 2019
UL http://www.ajnr.org/content/40/2/353.abstract
AB BACKGROUND AND PURPOSE: In recent years, effort has been made to study 3D biometry as a method for fetal brain assessment. In this study, we aimed to compare brain volumes of fetuses with cytomegalovirus infection and noninfected controls. Also, we wanted to assess whether there is a correlation to their neurodevelopmental outcome as observed after several years.MATERIALS AND METHODS: A retrospective cohort study examined MR imaging brain scans of 42 fetuses (at 30–34 weeks' gestational age) that were diagnosed with intrauterine cytomegalovirus infection. Volumetric measurements of 6 structures were assessed using a semiautomated designated program and were compared with a control group of 50 fetuses. Data collected included prenatal history and MR imaging and sonographic and neurodevelopmental follow-up.RESULTS: We found that all brain volumes measured were smaller in the cytomegalovirus-infected group and that there was a correlation between smaller cerebellar volume and lower Vineland II Adaptive Behavior Scales questionnaire scores, especially in the fields of daily living and communication skills.CONCLUSIONS: In this study, we found that brain volumes are affected by intrauterine cytomegalovirus infection and that it has a developmental prognostic meaning. Such information, which should be supported by further research, may help clinicians further analyze imaging data to treat and make a better assessment of these fetuses.CMVcytomegalovirusCVcerebellum volumeICCintraclass correlation coefficientLEBVleft eyeball volumeLHVleft hemisphere volumeREBVright eyeball volumeRHVright hemisphere volumeSTVsupratentorial volumeVABS-IIVineland II Adaptive Behavior Scale