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RT Journal Article
SR Electronic
T1 Dynamic Contrast-Enhanced MRI Reveals Unique Blood-Brain Barrier Permeability Characteristics in the Hippocampus in the Normal Brain
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 408
OP 411
DO 10.3174/ajnr.A5962
VO 40
IS 3
A1 Ivanidze, J.
A1 Mackay, M.
A1 Hoang, A.
A1 Chi, J.M.
A1 Cheng, K.
A1 Aranow, C.
A1 Volpe, B.
A1 Diamond, B.
A1 Sanelli, P.C.
YR 2019
UL http://www.ajnr.org/content/40/3/408.abstract
AB SUMMARY: We report a prospective dynamic contrast-enhanced MR imaging analysis of region-specific blood-brain barrier permeability in 5 healthy subjects. By means of standardized postprocessing and ROI sampling methods, the hippocampi revealed significantly elevated area under the dynamic contrast-enhanced curve and significantly increased blood-brain barrier permeability metrics (volume transfer constant and volume in the extravascular extracellular space) from model-based quantitation. These findings suggest unique blood-brain barrier permeability characteristics in the hippocampus, which are concordant with previous animal studies, potentially laying the groundwork for future studies assessing patient populations in which hippocampal pathology plays a role.BBBPblood-brain barrier permeabilityDCEdynamic contrast-enhancedKtransvolume transfer constantSLEsystemic lupus erythematosusVEvolume in the extravascular extracellular space