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PT  - JOURNAL ARTICLE
AU  - Szikora, I.
AU  - Seifert, P.
AU  - Hanzely, Z.
AU  - Kulcsar, Z.
AU  - Berentei, Z.
AU  - Marosfoi, M.
AU  - Czirjak, S.
AU  - Vajda, J.
AU  - Nyary, I.
TI  - Histopathologic Evaluation of Aneurysms Treated with Guglielmi Detachable Coils or Matrix Detachable Microcoils
DP  - 2006 Feb 01
TA  - American Journal of Neuroradiology
PG  - 283--288
VI  - 27
IP  - 2
4099  - http://www.ajnr.org/content/27/2/283.short
4100  - http://www.ajnr.org/content/27/2/283.full
SO  - Am. J. Neuroradiol.2006 Feb 01; 27
AB  - BACKGROUND AND PURPOSE: The purpose of this study was to evaluate the degree of organization and fibrocellular tissue development in aneurysms treated with bare platinum or biologically active microcoils.METHODS: Twelve aneurysms were removed at autopsy between 1–18 days and another 2 between 2–3 months posttreatment. Four aneurysms were surgically removed between 6 months and 3 years following treatment. One aneurysm removed at 8 days and another at 6 months were treated with bioactive (Matrix) coils; the other 16 with bare platinum (Guglielmi detachable coils; GDCs). All specimens were embedded in plastic, stained with hematoxilin-eosin and elastin and examined by light microscopy.RESULTS: All specimens removed within 3 weeks demonstrated intra-aneurysmal thrombus, without signs of organization or fibrotic tissue formation over the neck regardless of the type of coils used. In the GDC-treated aneurysms, evidence of early thrombus organization was observed within 2–3 months, and completed yet imperfect fibrocellular reaction together with residual thrombus at 2–3 years. In the Matrix-treated specimens, the aneurysm cavity was completely filled with granulation tissue corresponding to still ongoing fibrocellular reaction at 6 months, including newly formed blood vessels, smooth muscle cells, and collagen deposition without signs of residual thrombus.CONCLUSIONS: Our results indicate that in aneurysms treated with bare platinum coils thrombus organization does not occur until late after treatment and may remain imperfect for years. In one aneurysm studied 8 days following treatment with Matrix coils, no difference was noted compared to aneurysms treated with bare platinum coils. In another aneurysm examined 6 months following packing with Matrix coils, the histologic changes support the hypothesis that the biologically active polymer may accelerate aneurysm healing.