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PT  - JOURNAL ARTICLE
AU  - Choi, C.G.
AU  - Lee, D.H.
AU  - Lee, J.H.
AU  - Pyun, H.W.
AU  - Kang, D.W.
AU  - Kwon, S.U.
AU  - Kim, J.K.
AU  - Kim, S.J.
AU  - Suh, D.C.
TI  - Detection of Intracranial Atherosclerotic Steno-Occlusive Disease with 3D Time-of-Flight Magnetic Resonance Angiography with Sensitivity Encoding at 3T
DP  - 2007 Mar 01
TA  - American Journal of Neuroradiology
PG  - 439--446
VI  - 28
IP  - 3
4099  - http://www.ajnr.org/content/28/3/439.short
4100  - http://www.ajnr.org/content/28/3/439.full
SO  - Am. J. Neuroradiol.2007 Mar 01; 28
AB  - BACKGROUND AND PURPOSE: The spatial resolution of 3D time-of-flight MR angiography (TOF-MRA) can be improved within a reasonable examination time by combining 3T and sensitivity encoding technique. We evaluated the diagnostic performance of high-resolution 3D TOF-MRA at 3T in patients with suspected atherosclerotic steno-occlusive disease of the intracranial arteries.MATERIALS AND METHODS: We assessed 160 arteries in 39 patients: 68 distal internal carotid arteries, 68 middle cerebral arteries, and 24 vertebrobasilar arteries. The measured voxel size of 3D TOF-MRA was 0.28 × 0.56 × 1.2 mm3. Steno-occlusive disease was assessed independently by 2 observers using conventional angiography as the reference standard.RESULTS: According to observers 1 and 2, respectively, 3D TOF-MRA at 3T had a sensitivity of 78%/85% (21/27, 23/27), a specificity of 95%/95% (126/133, 127/133), a positive predictive value of 75%/79% (21/28, 23/29), and a negative predictive value of 95%/97% (126/132, 127/131), using a 50%–99% threshold of diameter stenosis. For detection of complete occlusion, according to observers 1 and 2, respectively, 3D TOF-MRA at 3T had a sensitivity of 100% (13/13), a specificity of 99% (145/147), a positive predictive value of 87% (13/15), and a negative predictive value of 100% (145/145). Interobserver agreement of 3D TOF-MRA was excellent (κ = 0.81).CONCLUSION: High-resolution 3D TOF-MRA with sensitivity encoding at 3T can be used as a reliable diagnostic tool for the detection of clinically significant steno-occlusive disease of major intracranial arteries.