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PT  - JOURNAL ARTICLE
AU  - Cohen, B.A.
AU  - Inglese, M.
AU  - Rusinek, H.
AU  - Babb, J.S.
AU  - Grossman, R.I.
AU  - Gonen, O.
TI  - Proton MR Spectroscopy and MRI-Volumetry in Mild Traumatic Brain Injury
DP  - 2007 May 01
TA  - American Journal of Neuroradiology
PG  - 907--913
VI  - 28
IP  - 5
4099  - http://www.ajnr.org/content/28/5/907.short
4100  - http://www.ajnr.org/content/28/5/907.full
SO  - Am. J. Neuroradiol.2007 May 01; 28
AB  - BACKGROUND AND PURPOSE: More than 85% of brain traumas are classified as “mild”; MR imaging findings are minimal if any and do not correspond to clinical symptoms. Our goal, therefore, was to quantify the global decline of the neuronal marker N-acetylaspartate (NAA), as well as gray (GM) and white matter (WM) atrophy after mild traumatic brain injury (mTBI).MATERIALS AND METHODS: Twenty patients (11 male, 9 female; age range, 19−57 years; median, 35 years) with mTBI (Glasgow Coma Scale score 13−15 with loss of consciousness for at least 30 seconds) and 19 age- and sex-matched control subjects were studied. Seven patients were studied within 9 days of TBI; the other 13 ranged from 1.2 months to 31.5 years (average and median of 4.6 and 1.7 years, respectively) after injury. Whole-brain NAA (WBNAA) concentration was obtained in all subjects with nonlocalizing proton MR spectroscopy. Brain volume and GM and WM fractions were segmented from T1-weighted MR imaging and normalized to the total intracranial volume, suitable for intersubject comparisons. The data were analyzed with least squares regression.RESULTS: Patients with mTBI exhibited, on average, a 12% WBNAA deficit that increased with age, compared with the control subjects (p &amp;lt; .05). Adjusted for age effects, patients also suffered both global atrophy (−1.09%/year; P = .029) and GM atrophy (−0.89%/year; P = .042). Patients with and without visible MR imaging pathology, typically punctate foci of suspected shearing injury, were indistinguishable in both atrophy and WBNAA.CONCLUSION: WBNAA detected neuronal/axonal injury beyond the minimal focal MR-visible lesions in mTBI. Combined with GM atrophy, the findings may provide further, noninvasive insight into the nature and progression of mTBI.