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PT  - JOURNAL ARTICLE
AU  - Morton, D.W.
AU  - Keogh, B.
AU  - Lim, K.
AU  - Maravilla, K.R.
TI  - Functional Brain Imaging Using a Long Intravenous Half-Life Gadolinium-Based Contrast Agent
DP  - 2006 Aug 01
TA  - American Journal of Neuroradiology
PG  - 1467--1471
VI  - 27
IP  - 7
4099  - http://www.ajnr.org/content/27/7/1467.short
4100  - http://www.ajnr.org/content/27/7/1467.full
SO  - Am. J. Neuroradiol.2006 Aug 01; 27
AB  - PURPOSE: We describe a technique for functional MR imaging (fMRI) with high spatial and temporal resolution using a long intravascular half-life gadolinium-based contrast agent, MS-325.METHODS: All fMRI measurements used a rat model of sensory cortex activation with forepaw electrical stimulation under α-chloralose anesthesia. Standard blood oxygen level–dependent (BOLD) fMRI measurement was initially performed. MS-325 was then intravenously administered and a MS-325 fMRI measurement was performed by using a 3D gradient-echo sequence.RESULTS: We found that a dose of 0.1 mmol/kg MS-325 produced adequate signal intensity changes in rat sensory cortex to demonstrate activations. Using a boxcar stimulation pattern with a standard correlation analysis, the locations of the most significantly activated voxels (ie, highest Z score) in the MS-325 and BOLD fMRI measurements were not significantly different.CONCLUSIONS: MS-325 fMRI has the advantage of using a T1-weighted sequence, rather than the highly T2*-weighted sequences used in other common fMRI techniques. This could reduce the susceptibility artifacts associated with fMRI.