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PT  - JOURNAL ARTICLE
AU  - Zaharchuk, G.
TI  - Theoretical Basis of Hemodynamic MR Imaging Techniques to Measure Cerebral Blood Volume, Cerebral Blood Flow, and Permeability
AID  - 10.3174/ajnr.A0831
DP  - 2007 Nov 01
TA  - American Journal of Neuroradiology
PG  - 1850--1858
VI  - 28
IP  - 10
4099  - http://www.ajnr.org/content/28/10/1850.short
4100  - http://www.ajnr.org/content/28/10/1850.full
SO  - Am. J. Neuroradiol.2007 Nov 01; 28
AB  - SUMMARY: Cerebrovascular hemodynamic assessment adds new information to standard anatomic MR imaging and improves patient care. This article reviews the theoretic underpinnings of several potentially quantitative MR imaging–based methods that shed light on the hemodynamic status of the brain, including cerebral blood flow (CBF), cerebral blood volume (CBV), and contrast agent permeability. Techniques addressed include dynamic susceptibility contrast (which most simply and accurately estimates CBV), arterial spin labeling (a powerful method to measure CBF), and contrast-enhanced methods to derive permeability parameters such as the transport constant Ktrans.