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PT  - JOURNAL ARTICLE
AU  - McKinney, A.M.
AU  - Reichert, P.
AU  - Short, J.
AU  - Dhurairaj, T.
AU  - SantaCruz, K.
AU  - McKinney, Z.
AU  - Kieffer, S.
TI  - Metachronous, Multicentric Giant Cell Tumor of the Sphenoid Bone with Histologic, CT, MR Imaging, and Positron-Emission Tomography/CT Correlation
DP  - 2006 Nov 01
TA  - American Journal of Neuroradiology
PG  - 2199--2201
VI  - 27
IP  - 10
4099  - http://www.ajnr.org/content/27/10/2199.short
4100  - http://www.ajnr.org/content/27/10/2199.full
SO  - Am. J. Neuroradiol.2006 Nov 01; 27
AB  - SUMMARY: Giant cell tumor (GCT) of the sphenoid bone is a relatively rare entity and metachronous multicentric GCT of the sphenoid is even rarer; we are aware of only 3 previous cases in the literature. We describe here a tumor of the sphenoid bone that was identified 15 years after multiple resections of a GCT of the left inferior pubic ramus. Correlation is made between the histopathologic findings, MR imaging of the brain, CT of the head, and fusion positron-emission tomography (PET)/CT scan performed with fluorine-18 fluoro-2-deoxy-D-glucose (18F-FDG). This report is the first to describe the appearance of a GCT of the sphenoid bone on a fusion PET/CT examination. High metabolic activity in the base of the skull adjacent to the middle cranial fossa was demonstrated in a fashion similar to that of the known pelvic lesion. This case also demonstrates that the increased metabolic activity seen in a GCT of the sphenoid bone may be partially obscured by the adjacent physiologic high metabolic activity of the brain.