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PT  - JOURNAL ARTICLE
AU  - Li, X.
AU  - Wang, D.
AU  - Liao, S.
AU  - Guo, L.
AU  - Xiao, X.
AU  - Liu, X.
AU  - Xu, Y.
AU  - Hua, J.
AU  - Pillai, J.J.
AU  - Wu, Y.
TI  - Discrimination between Glioblastoma and Solitary Brain Metastasis: Comparison of Inflow-Based Vascular-Space-Occupancy and Dynamic Susceptibility Contrast MR Imaging
AID  - 10.3174/ajnr.A6466
DP  - 2020 Apr 01
TA  - American Journal of Neuroradiology
PG  - 583--590
VI  - 41
IP  - 4
4099  - http://www.ajnr.org/content/41/4/583.short
4100  - http://www.ajnr.org/content/41/4/583.full
SO  - Am. J. Neuroradiol.2020 Apr 01; 41
AB  - BACKGROUND AND PURPOSE: Accurate differentiation between glioblastoma and solitary brain metastasis is of vital importance clinically. This study aimed to investigate the potential value of the inflow-based vascular-space-occupancy MR imaging technique, which has no need for an exogenous contrast agent, in differentiating glioblastoma and solitary brain metastasis and to compare it with DSC MR imaging.MATERIALS AND METHODS: Twenty patients with glioblastoma and 22 patients with solitary brain metastasis underwent inflow-based vascular-space-occupancy and DSC MR imaging with a 3T clinical scanner. Two neuroradiologists independently measured the maximum inflow-based vascular-space-occupancy–derived arteriolar CBV and DSC-derived CBV values in intratumoral regions and peritumoral T2-hyperintense regions, which were normalized to the contralateral white matter (relative arteriolar CBV and relative CBV, inflow-based vascular-space-occupancy relative arteriolar CBV, and DSC-relative CBV). The intraclass correlation coefficient, Student t test, or Mann-Whitney U test and receiver operating characteristic analysis were performed.RESULTS: All parameters of both regions had good or excellent interobserver reliability (0.74∼0.89). In peritumoral T2-hyperintese regions, DSC-relative CBV (P &amp;lt; .001), inflow-based vascular-space-occupancy arteriolar CBV (P = .001), and relative arteriolar CBV (P = .005) were significantly higher in glioblastoma than in solitary brain metastasis, with areas under the curve of 0.94, 0.83, and 0.72 for discrimination, respectively. In the intratumoral region, both inflow-based vascular-space-occupancy arteriolar CBV and relative arteriolar CBV were significantly higher in glioblastoma than in solitary brain metastasis (both P &amp;lt; .001), with areas under the curve of 0.91 and 0.90, respectively. Intratumoral DSC-relative CBV showed no significant difference (P = .616) between the 2 groups.CONCLUSIONS: Inflow-based vascular-space-occupancy has the potential to discriminate glioblastoma from solitary brain metastasis, especially in the intratumoral region.AUCarea under the curveCBVaarteriolar CBVGBMglioblastomaiVASOinflow-based vascular-space-occupancyrCBVrelative CBVrCBVarelative arteriolar CBVPTHperitumoral T2-hyperintesity regionSBMsolitary brain metastasis