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PT  - JOURNAL ARTICLE
AU  - Ngai, S.
AU  - Tang, Y.M.
AU  - Du, L.
AU  - Stuckey, S.
TI  - Hyperintensity of the Middle Cerebellar Peduncles on Fluid-Attenuated Inversion Recovery Imaging: Variation with Age and Implications for the Diagnosis of Multiple System Atrophy
DP  - 2006 Nov 01
TA  - American Journal of Neuroradiology
PG  - 2146--2148
VI  - 27
IP  - 10
4099  - http://www.ajnr.org/content/27/10/2146.short
4100  - http://www.ajnr.org/content/27/10/2146.full
SO  - Am. J. Neuroradiol.2006 Nov 01; 27
AB  - BACKGROUND AND PURPOSE:T2 hyperintensity of the middle cerebellar peduncle (MCP) is described in a number of diseases, including multiple system atrophy (MSA). We hypothesize that mild MCP hyperintensity on fluid-attenuated inversion recovery (FLAIR) imaging can be a normal finding. To our knowledge, a detailed study of the prevalence of this finding in various age groups with the FLAIR sequence has not been described.METHODS:One hundred twenty-two patients underwent an axial FLAIR examination of the brain as part of either a hearing loss or tinnitus work-up (ie, to exclude an acoustic neuroma or a retrocochlear cause). Subjects aged 15–78 years were included to reflect an even spread through the decades and were divided into 6 age groups. A radiologist and an MR imaging fellow graded the examinations subjectively, blinded to age: 0 for normal or 1 for the presence of MCP hyperintensity if the increased signal intensity was greater than that of adjacent pons and cerebellar white matter. Spearman rank correlation test of MCP hyperintensity with age and analysis of variance (ANOVA) were performed.RESULTS:Of 122 patients, we identified 17 with MCP FLAIR hyperintensity. None of these patients had a clinical condition that could cause MCP hyperintensity. MCP hyperintensity did not show a statistically significant correlation with age (r = 0.05, P = .62). Patients were divided into 6 age groups, and ANOVA showed no statistically significant difference in the incidence of MCP hyperintensity between different age groups (P = .95). However, results were highly reproducible with excellent interobserver correlation (r = 0.97, P &amp;lt; .001).CONCLUSIONS:Mild MCP FLAIR hyperintensity can occur normally, and this finding shows no relationship with age.