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RT Journal Article
SR Electronic
T1 Prediction of Outcome Using Quantified Blood Volume in Aneurysmal SAH
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 1015
OP 1021
DO 10.3174/ajnr.A6575
VO 41
IS 6
A1 van der Steen, W.E.
A1 Marquering, H.A.
A1 Ramos, L.A.
A1 van den Berg, R.
A1 Coert, B.A.
A1 Boers, A.M.M.
A1 Vergouwen, M.D.I.
A1 Rinkel, G.J.E.
A1 Velthuis, B.K.
A1 Roos, Y.B.W.E.M.
A1 Majoie, C.B.L.M.
A1 Vandertop, W.P.
A1 Verbaan, D.
YR 2020
UL http://www.ajnr.org/content/41/6/1015.abstract
AB BACKGROUND AND PURPOSE: In patients with SAH, the amount of blood is strongly associated with clinical outcome. However, it is commonly estimated with a coarse grading scale, potentially limiting its predictive value. Therefore, we aimed to develop and externally validate prediction models for clinical outcome, including quantified blood volumes, as candidate predictors.MATERIALS AND METHODS: Clinical and radiologic candidate predictors were included in a logistic regression model. Unfavorable outcome was defined as a modified Rankin Scale score of 4–6. An automatic hemorrhage-quantification algorithm calculated the total blood volume. Blood was manually classified as cisternal, intraventricular, or intraparenchymal. The model was selected with bootstrapped backward selection and validated with the R2, C-statistic, and calibration plots. If total blood volume remained in the final model, its performance was compared with models including location-specific blood volumes or the modified Fisher scale.RESULTS: The total blood volume, neurologic condition, age, aneurysm size, and history of cardiovascular disease remained in the final models after selection. The externally validated predictive accuracy and discriminative power were high (R2 = 56% ± 1.8%; mean C-statistic = 0.89 ± 0.01). The location-specific volume models showed a similar performance (R2 = 56% ± 1%, P = .8; mean C-statistic = 0.89 ± 0.00, P = .4). The modified Fisher models were significantly less accurate (R2 = 45% ± 3%, P &lt; .001; mean C-statistic = 0.85 ± 0.01, P = .03).CONCLUSIONS: The total blood volume–based prediction model for clinical outcome in patients with SAH showed a high predictive accuracy, higher than a prediction model including the commonly used modified Fisher scale.aSAHaneurysmal subarachnoid hemorrhageIPHintraparenchymal hemorrhageIQRinterquartile rangeIVHintraventricular hemorrhageTBVtotal blood volumeWFNSWorld Federation of Neurosurgical Societies