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PT  - JOURNAL ARTICLE
AU  - Takanashi, J.
AU  - Tada, H.
AU  - Terada, H.
AU  - Barkovich, A.J.
TI  - Excitotoxicity in Acute Encephalopathy with Biphasic Seizures and Late Reduced Diffusion
AID  - 10.3174/ajnr.A1247
DP  - 2009 Jan 01
TA  - American Journal of Neuroradiology
PG  - 132--135
VI  - 30
IP  - 1
4099  - http://www.ajnr.org/content/30/1/132.short
4100  - http://www.ajnr.org/content/30/1/132.full
SO  - Am. J. Neuroradiol.2009 Jan 01; 30
AB  - SUMMARY: Acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) is a recently described clinicoradiologic syndrome. MR spectroscopy in 3 patients with AESD revealed decreased N-acetylaspartate (NAA) and elevated glutamine/glutamate complex (Glx) during the week of presentation. Afterward, Glx normalized, whereas NAA remained low in 2 patients with neurologic sequelae but nearly normalized in the third patient without neurologic sequelae. These findings support the hypothesis that excitotoxic neuronal damage plays an important role in the pathogenesis of AESD and suggest that MR spectroscopy might be predictive of outcome.