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RT Journal Article
SR Electronic
T1 Focal Leptomeningeal Disease with Perivascular Invasion in <em>EGFR</em>-Mutant Non-Small-Cell Lung Cancer
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 1430
OP 1433
DO 10.3174/ajnr.A6640
VO 41
IS 8
A1 Dasgupta, A.
A1 Moraes, F.Y.
A1 Rawal, S.
A1 Diamandis, P.
A1 Shultz, D.B.
YR 2020
UL http://www.ajnr.org/content/41/8/1430.abstract
AB SUMMARY: We report a previously undescribed pattern of brain metastases in patients with epidermal growth factor receptor–mutated non-small-cell lung cancer treated with tyrosine kinase inhibitors and radiation therapy. These highly distinct lesions appear to spread focally within the leptomeninges, with invasion along the perivascular spaces (FLIP). The survival of patients with FLIP was significantly better compared with patients with classic leptomeningeal disease (median survival, 21 versus 3 months; P = .003). It is unclear whether this pattern of growth is unique to epidermal growth factor receptor–mutated non-small-cell lung cancer.EGFRmepidermal growth factor receptor–mutatedcLMDclassic leptomeningeal diseaseFLIPfocal leptomeningeal involvement with invasion of the perivascular spaceNSCLCnon-small-cell lung cancerTKItyrosine kinase inhibitorsWBRTwhole-brain radiation