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PT  - JOURNAL ARTICLE
AU  - Desikan, R.S.
AU  - Cabral, H.J.
AU  - Fischl, B.
AU  - Guttmann, C.R.G.
AU  - Blacker, D.
AU  - Hyman, B.T.
AU  - Albert, M.S.
AU  - Killiany, R.J.
TI  - Temporoparietal MR Imaging Measures of Atrophy in Subjects with Mild Cognitive Impairment That Predict Subsequent Diagnosis of Alzheimer Disease
AID  - 10.3174/ajnr.A1397
DP  - 2009 Mar 01
TA  - American Journal of Neuroradiology
PG  - 532--538
VI  - 30
IP  - 3
4099  - http://www.ajnr.org/content/30/3/532.short
4100  - http://www.ajnr.org/content/30/3/532.full
SO  - Am. J. Neuroradiol.2009 Mar 01; 30
AB  - BACKGROUND AND PURPOSE: Mild cognitive impairment (MCI) represents a transitional state between normal aging and Alzheimer disease (AD). Our goal was to determine if specific temporoparietal regions can predict the time to progress from MCI to AD.MATERIALS AND METHODS: MR images from 129 individuals with MCI were analyzed to identify the volume of 14 neocortical and 2 non-neocortical brain regions, comprising the temporal and parietal lobes. In addition, 3 neuropsychological test scores were included to determine whether they would provide independent information. After a mean follow-up time of 5 years, 44 of these individuals had progressed to a diagnosis of AD.RESULTS: Cox proportional hazards models demonstrated significant effects for 6 MR imaging regions with the greatest differences being the following: the entorhinal cortex (hazard ratio [HR] = 0.54, P &amp;lt; .001), inferior parietal lobule (hazard ratio [HR] = 0.64, P &amp;lt; .005), and middle temporal gyrus (HR = 0.64, P &amp;lt; .004), indicating decreased risk with larger volumes. A multivariable model showed that a combination of the entorhinal cortex (HR = 0.60, P &amp;lt; .001) and the inferior parietal lobule (HR = 0.62, P &amp;lt; .01) was the best predictor of time to progress to AD. A multivariable model reiterated the importance of including both MR imaging and neuropsychological variables in the final model.CONCLUSIONS: These findings reaffirm the importance of the entorhinal cortex and present evidence for the importance of the inferior parietal lobule as a predictor of time to progress from MCI to AD. The inclusion of neuropsychological performance in the final model continues to highlight the importance of using these measures in a complementary fashion.