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RT Journal Article
SR Electronic
T1 Ipilimumab-Induced Hypophysitis: MR Imaging Findings
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 1751
OP 1753
DO 10.3174/ajnr.A1623
VO 30
IS 9
A1 Carpenter, K.J.
A1 Murtagh, R.D.
A1 Lilienfeld, H.
A1 Weber, J.
A1 Murtagh, F.R.
YR 2009
UL http://www.ajnr.org/content/30/9/1751.abstract
AB SUMMARY: Ipilimumab is a promising new immunotherapeutic antineoplastic agent with clinical activity in the treatment of metastatic melanoma and renal cell carcinoma. With advances in immunotherapy, however, a host of new side effects related to the mechanism of action of these drugs has appeared. At our institution, 3 patients presented with hypophysitis, which was attributed to an autoimmune process based on the documented relationship of the drug to other autoimmune phenomena and significant and rapid improvement with discontinuation of the drug and addition of steroids. We present the imaging findings in 3 patients with presumed ipilimumab-induced hypophysitis.