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PT  - JOURNAL ARTICLE
AU  - Dilba, K.
AU  - van Dam-Nolen, D.H.K.
AU  - van Dijk, A.C.
AU  - Kassem, M.
AU  - van der Steen, A.F.W.
AU  - Koudstaal, P.J.
AU  - Nederkoorn, P.J.
AU  - Hendrikse, J.
AU  - Kooi, M.E.
AU  - Wentzel, J.J.
AU  - van der Lugt, A.
TI  - Plaque Composition as a Predictor of Plaque Ulceration in Carotid Artery Atherosclerosis: The Plaque At RISK Study
AID  - 10.3174/ajnr.A6868
DP  - 2020 Nov 19
TA  - American Journal of Neuroradiology
4099  - http://www.ajnr.org/content/early/2020/11/19/ajnr.A6868.short
4100  - http://www.ajnr.org/content/early/2020/11/19/ajnr.A6868.full
AB  - BACKGROUND AND PURPOSE: Plaque ulceration is a marker of previous plaque rupture. We studied the association between atherosclerotic plaque composition at baseline and plaque ulceration at baseline and follow-up.MATERIALS AND METHODS: We included symptomatic patients with a carotid stenosis of &amp;lt;70% who underwent MDCTA and MR imaging at baseline (n = 180). MDCTA was repeated at 2 years (n = 73). We assessed the presence of ulceration using MDCTA. Baseline MR imaging was used to assess the vessel wall volume and the presence and volume of plaque components (intraplaque hemorrhage, lipid-rich necrotic core, and calcifications) and the fibrous cap status. Associations at baseline were evaluated with binary logistic regression and reported with an OR and its 95% CI. Simple statistical testing was performed in the follow-up analysis.RESULTS: At baseline, the prevalence of plaque ulceration was 27% (49/180). Increased wall volume (OR  = 12.1; 95% CI, 3.5–42.0), higher relative lipid-rich necrotic core (OR = 1.7; 95% CI, 1.3–2.2), higher relative intraplaque hemorrhage volume (OR = 1.7; 95% CI, 1.3–2.2), and a thin-or-ruptured fibrous cap (OR = 3.4; 95% CI, 1.7–6.7) were associated with the presence of ulcerations at baseline. In 8% (6/73) of the patients, a new ulcer developed. Plaques with a new ulceration at follow-up had at baseline a larger wall volume (1.04 cm3 [IQR, 0.97–1.16 cm3] versus 0.86 cm3 [IQR, 0.73–1.00 cm3]; P = .029), a larger relative lipid-rich necrotic core volume (23% [IQR, 13–31%] versus 2% [IQR, 0–14%]; P = .002), and a larger relative intraplaque hemorrhage volume (14% [IQR, 8–24%] versus 0% [IQR, 0–5%]; P &amp;lt; .001).CONCLUSIONS: Large atherosclerotic plaques and plaques with intraplaque hemorrhage and lipid-rich necrotic cores were associated with plaque ulcerations at baseline and follow-up.AUCarea under the curveIPHintraplaque hemorrhageIQRinterquartile rangeLRNClipid-rich necrotic coreTRFCthick versus thin-or-ruptured fibrous cap