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PT  - JOURNAL ARTICLE
AU  - Rapalino, O.
AU  - Weerasekera, A.
AU  - Moum, S.J.
AU  - Eikermann-Haerter, K.
AU  - Edlow, B.L.
AU  - Fischer, D.
AU  - Torrado-Carvajal, A.
AU  - Loggia, M.L.
AU  - Mukerji, S.S.
AU  - Schaefer, P.W.
AU  - Gonzalez, R.G.
AU  - Lev, M.H.
AU  - Ratai, E.-M.
TI  - Brain MR Spectroscopic Findings in 3 Consecutive Patients with COVID-19: Preliminary Observations
AID  - 10.3174/ajnr.A6877
DP  - 2021 Jan 01
TA  - American Journal of Neuroradiology
PG  - 37--41
VI  - 42
IP  - 1
4099  - http://www.ajnr.org/content/42/1/37.short
4100  - http://www.ajnr.org/content/42/1/37.full
SO  - Am. J. Neuroradiol.2021 Jan 01; 42
AB  - SUMMARY: Brain multivoxel MR spectroscopic imaging was performed in 3 consecutive patients with coronavirus disease 2019 (COVID-19). These included 1 patient with COVID-19-associated necrotizing leukoencephalopathy, another patient who had a recent pulseless electrical activity cardiac arrest with subtle white matter changes, and a patient without frank encephalopathy or a recent severe hypoxic episode. The MR spectroscopic imaging findings were compared with those of 2 patients with white matter pathology not related to Severe Acute Respiratory Syndrome coronavirus 2 infection and a healthy control subject. The NAA reduction, choline elevation, and glutamate/glutamine elevation found in the patient with COVID-19-associated necrotizing leukoencephalopathy and, to a lesser degree, the patient with COVID-19 postcardiac arrest, follow a similar pattern as seen with the patient with delayed posthypoxic leukoencephalopathy. Lactate elevation was most pronounced in the patient with COVID-19 necrotizing leukoencephalopathy.COVID-19coronavirus disease 2019DPLdelayed posthypoxic leukoencephalopathyLaclactatePEApulseless electrical activitySAEsepsis-associated encephalopathySARS-CoV-2Severe Acute Respiratory Syndrome coronavirus 2