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PT  - JOURNAL ARTICLE
AU  - Han, M.
AU  - Ha, E.J.
AU  - Park, J.H.
TI  - Computer-Aided Diagnostic System for Thyroid Nodules on Ultrasonography: Diagnostic Performance Based on the Thyroid Imaging Reporting and Data System Classification and Dichotomous Outcomes
AID  - 10.3174/ajnr.A6922
DP  - 2021 Mar 01
TA  - American Journal of Neuroradiology
PG  - 559--565
VI  - 42
IP  - 3
4099  - http://www.ajnr.org/content/42/3/559.short
4100  - http://www.ajnr.org/content/42/3/559.full
SO  - Am. J. Neuroradiol.2021 Mar 01; 42
AB  - BACKGROUND AND PURPOSE: Artificial intelligence-based computer-aided diagnostic systems have been introduced for thyroid cancer diagnosis. Our aim was to compare the diagnostic performance of a commercially available computer-aided diagnostic system and radiologist-based assessment for the detection of thyroid cancer based on the Thyroid Imaging Reporting and Data Systems (TIRADS) and dichotomous outcomes.MATERIALS AND METHODS: In total, 372 consecutive patients with 454 thyroid nodules were enrolled. The computer-aided diagnostic system was set up to render a possible diagnosis in 2 formats, the Korean Society of Thyroid Radiology (K)-TIRADS and the American Thyroid Association (ATA)-TIRADS-classifications, and dichotomous outcomes (possibly benign or possibly malignant).RESULTS: The diagnostic sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of the computer-aided diagnostic system for thyroid cancer were, respectively, 97.6%, 21.6%, 42.0%, 93.9%, and 49.6% for K-TIRADS; 94.6%, 29.6%, 43.9%, 90.4%, and 53.5% for ATA-TIRADS; and 81.4%, 81.9%, 72.3%, 88.3%, and 81.7% for dichotomous outcomes. The sensitivities of the computer-aided diagnostic system did not differ significantly from those of the radiologist (all P &amp;gt; .05); the specificities and accuracies were significantly lower than those of the radiologist (all P &amp;lt; .001). Unnecessary fine-needle aspiration rates were lower for the dichotomous outcome characterizations, particularly for those performed by the radiologist. The interobserver agreement for the description of K-TIRADS and ATA-TIRADS classifications was fair-to-moderate, but the dichotomous outcomes were in substantial agreement.CONCLUSIONS: The diagnostic performance of the computer-aided diagnostic system varies in terms of TIRADS classification and dichotomous outcomes and relative to radiologist-based assessments. Clinicians should know about the strengths and weaknesses associated with the diagnosis of thyroid cancer using computer-aided diagnostic systems.AIartificial intelligenceATAAmerican Thyroid AssociationCADcomputer-aided diagnosisFNAfine-needle aspirationKKoreanTIRADSThyroid Imaging Reporting and Data SystemUSultrasonography