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PT  - JOURNAL ARTICLE
AU  - Simao, G.N.
AU  - Zarei Mahmoodabadi, S.
AU  - Snead, O.C.
AU  - Go, C.
AU  - Widjaja, E.
TI  - Abnormal Axial Diffusivity in the Deep Gray Nuclei and Dorsal Brain Stem in Infantile Spasm Treated with Vigabatrin
AID  - 10.3174/ajnr.A2224
DP  - 2011 Jan 01
TA  - American Journal of Neuroradiology
PG  - 199--203
VI  - 32
IP  - 1
4099  - http://www.ajnr.org/content/32/1/199.short
4100  - http://www.ajnr.org/content/32/1/199.full
SO  - Am. J. Neuroradiol.2011 Jan 01; 32
AB  - SUMMARY: We evaluated the DTI changes in the deep gray nuclei and dorsal brain stem, which demonstrated abnormal T2 and/or diffusion signal intensity, in 6 patients with infantile spasm treated with vigabatrin compared with 6 age-matched controls. Regions of interest were placed in the globi pallidi, thalami, and dorsal brain stem; FA, trace, D‖, and D⊥ were measured. Patients on vigabatrin had significantly lower FA in both globi pallidi (P = .01) and the dorsal brain stem (P &amp;lt; .01), significantly lower trace in both globi pallidi (P = .01) and the thalami (P = .02 and .01 for right and left, respectively), and significantly lower D‖ in both globi pallidi (P ≤ .01), the thalami (P &amp;lt; .01), and the dorsal brain stem (P = .03). There were no significant differences in D⊥ of the globi pallidi, thalami, or dorsal brain stem in patients compared with controls. The findings suggest that axonal changes play a greater role in the observed abnormal signal intensity, with lesser contribution from myelin changes. D‖axial diffusivityD⊥radial diffusivityDBdorsal brain stemDTIdiffusion tensor imagingFAfractional anisotropyGABAγ-aminobutyric acidGPglobi pallidiICCintraclass correlation coefficientISinfantile spasmLleftMRIMR imagingRrightThalthalamiTSCtuberous sclerosis complexVGBvigabatrinVGB-Ptpatients on vigabatrin therapy with abnormal T2 and/or diffusion signal intensity on MR imaging