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PT  - JOURNAL ARTICLE
AU  - Anderson, A B
AU  - Tran, T H
AU  - Hamilton, M J
AU  - Chudzik, S J
AU  - Hastings, B P
AU  - Melchior, M J
AU  - Hergenrother, R W
TI  - Platelet deposition and fibrinogen binding on surfaces coated with heparin or friction-reducing polymers.
DP  - 1996 May 01
TA  - American Journal of Neuroradiology
PG  - 859--863
VI  - 17
IP  - 5
4099  - http://www.ajnr.org/content/17/5/859.short
4100  - http://www.ajnr.org/content/17/5/859.full
SO  - Am. J. Neuroradiol.1996 May 01; 17
AB  - The blood-contacting properties of polyethylene coated with a lubricious hydrophilic coating; an uncoated polyethylene; or a photoheparin-treated polyethylene-negative control sample were compared by measuring fibrinogen adsorption, antifibrinogen binding, and platelet attachment from human plasma. The polyethylene surfaces coated with a hydrophilic polymer were found to be similar to surfaces coated with heparin. Fibrinogen adsorption on the hydrophilic coating was 60% lower than adsorption on either the uncoated or heparin-coated polyethylene samples. Antifibrinogen binding from buffer to the hydrophilic coating was also reduced more than 85% from binding to uncoated polyethylene samples. Both the hydrophilic coating and heparin coating showed a reduction in platelet attachment by a factor of 100 over the uncoated sample as well as significantly reduced platelet activation.