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RT Journal Article
SR Electronic
T1 Platelet deposition and fibrinogen binding on surfaces coated with heparin or friction-reducing polymers.
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 859
OP 863
VO 17
IS 5
A1 Anderson, A B
A1 Tran, T H
A1 Hamilton, M J
A1 Chudzik, S J
A1 Hastings, B P
A1 Melchior, M J
A1 Hergenrother, R W
YR 1996
UL http://www.ajnr.org/content/17/5/859.abstract
AB The blood-contacting properties of polyethylene coated with a lubricious hydrophilic coating; an uncoated polyethylene; or a photoheparin-treated polyethylene-negative control sample were compared by measuring fibrinogen adsorption, antifibrinogen binding, and platelet attachment from human plasma. The polyethylene surfaces coated with a hydrophilic polymer were found to be similar to surfaces coated with heparin. Fibrinogen adsorption on the hydrophilic coating was 60% lower than adsorption on either the uncoated or heparin-coated polyethylene samples. Antifibrinogen binding from buffer to the hydrophilic coating was also reduced more than 85% from binding to uncoated polyethylene samples. Both the hydrophilic coating and heparin coating showed a reduction in platelet attachment by a factor of 100 over the uncoated sample as well as significantly reduced platelet activation.