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RT Journal Article
SR Electronic
T1 Identification of <em>BRAF p. V600E</em>-Mutant and Wild-Type by MR Imaging in Pleomorphic Xanthoastrocytoma and Anaplastic Pleomorphic Xanthoastrocytoma
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 2152
OP 2159
DO 10.3174/ajnr.A7324
VO 42
IS 12
A1 Huang, W.
A1 Cai, J.
A1 Lin, N.
A1 Xu, Y.
A1 Wang, H.
A1 Wu, Z.
A1 Kang, D.
YR 2021
UL http://www.ajnr.org/content/42/12/2152.abstract
AB BACKGROUND AND PURPOSE: Compared with BRAF p. V600E wild-type pleomorphic xanthoastrocytoma, BRAF p. V600E-mutant pleomorphic xanthoastrocytoma showed a higher survival rate. In this study, we focused on finding preoperative MR imaging differences between BRAF p. V600E mutant and wild-type in pleomorphic xanthoastrocytoma and anaplastic pleomorphic xanthoastrocytoma.MATERIALS AND METHODS: Twenty-three patients with pathologically confirmed pleomorphic xanthoastrocytoma or anaplastic pleomorphic xanthoastrocytoma in our hospital were retrospectively analyzed from January 2015 to December 2020. They were divided into a BRAF p. V600E-mutant group (including 6 pleomorphic xanthoastrocytomas and 5 anaplastic pleomorphic xanthoastrocytomas) and a wild-type group (including 8 pleomorphic xanthoastrocytomas and 4 anaplastic pleomorphic xanthoastrocytomas). The preoperative MR imaging characteristics of these groups were statistically compared.RESULTS: The wild-type pleomorphic xanthoastrocytoma group presented with more aggressive conventional and advanced MR imaging features than the mutant pleomorphic xanthoastrocytoma group, including greater mean maximum tumor diameter (3.1 [SD, 0.9] cm versus 1.7 [SD, 0.4 ] cm, P &lt; .05), more frequent heterogeneous contrast enhancement of solid portions (100% versus 0%, P &lt; .001), more obvious peritumoral edema (mean, [2.1 SD, 0.7] cm versus 0.6 [SD, 0.2] cm, P &lt; .01), and lower mean minimum relative ADC (896 [SD, 86] versus 988 [SD, 73], P &lt; .05) and mean relative ADC (1060 [SD, 159] versus 1248 [SD, 116], P &lt; .05) on DWI. However, there was no significant difference in either conventional or advanced MR imaging features between the wild-type anaplastic pleomorphic xanthoastrocytoma group and the mutant anaplastic pleomorphic xanthoastrocytoma group.CONCLUSIONS: Neurosurgeons should carefully interpret MR images before an operation and select appropriate surgical strategies according to genotype prediction.ADCmeanmean relative ADCADCminminimum relative ADCAPXAanaplastic pleomorphic xanthoastrocytomaPXApleomorphic xanthoastrocytomaWHOWorld Health Organization