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RT Journal Article
SR Electronic
T1 Magnetization Transfer Imaging Provides No Evidence of Demyelination in Methotrexate-Induced Encephalopathy
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP E110
OP E112
DO 10.3174/ajnr.A2181
VO 32
IS 6
A1 Miese, F.R.
A1 Schuster, F.R.
A1 Pierstorff, K.
A1 Karenfort, M.
A1 Laws, H.J.
A1 Borkhardt, A.
A1 Saleh, A.
YR 2011
UL http://www.ajnr.org/content/32/6/E110.abstract
AB SUMMARY: Subacute MTX-induced encephalopathy is characterized by an abrupt onset of focal neurologic deficits within days after intrathecal or systemic therapy. Demyelination is one proposed mechanism. We describe the neuroimaging features of 2 patients with clinical symptoms of subacute encephalopathy after intrathecal and systemic MTX therapy. DWI showed restricted diffusion, indicating cytotoxic edema. MTI yielded no evidence of demyelination in either patient because there was no loss of MTR in areas of restricted diffusion. ADCapparent diffusion coefficientALLacute lymphoblastic leukemiaDWIdiffusion-weighted imagingITintrathecalIVintravenousMTImagnetization transfer imagingMTRmagnetization transfer ratioMTXmethotrexate