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PT  - JOURNAL ARTICLE
AU  - Wootton-Gorges, S.L.
AU  - Buonocore, M.H.
AU  - Caltagirone, R.A.
AU  - Kuppermann, N.
AU  - Glaser, N.S.
TI  - Progressive Decrease in &lt;em&gt;N&lt;/em&gt;-Acetylaspartate/Creatine Ratio in a Teenager with Type 1 Diabetes and Repeated Episodes of Ketoacidosis without Clinically Apparent Cerebral Edema: Evidence for Permanent Brain Injury
AID  - 10.3174/ajnr.A1829
DP  - 2010 Apr 01
TA  - American Journal of Neuroradiology
PG  - 780--781
VI  - 31
IP  - 4
4099  - http://www.ajnr.org/content/31/4/780.short
4100  - http://www.ajnr.org/content/31/4/780.full
SO  - Am. J. Neuroradiol.2010 Apr 01; 31
AB  - SUMMARY: Recent data suggest that DKA may contribute to cognitive impairment in children with type 1 DM. We measured the NAA/Cr ratio in a teenager during and following 2 separate episodes of DKA without clinically apparent cerebral edema. The NAA/Cr ratio decreased during DKA and improved following recovery. However, the NAA/Cr value was lower after the second episode of DKA (1.76) than after the first (1.97). These findings provide support for the hypothesis that neuronal injury may result from DKA. BUNblood urea nitrogenCrcreatineDKAdiabetic ketoacidosisDMdiabetes mellitusNAAN-acetylaspartate