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RT Journal Article
SR Electronic
T1 Progressive Decrease in <em>N</em>-Acetylaspartate/Creatine Ratio in a Teenager with Type 1 Diabetes and Repeated Episodes of Ketoacidosis without Clinically Apparent Cerebral Edema: Evidence for Permanent Brain Injury
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 780
OP 781
DO 10.3174/ajnr.A1829
VO 31
IS 4
A1 Wootton-Gorges, S.L.
A1 Buonocore, M.H.
A1 Caltagirone, R.A.
A1 Kuppermann, N.
A1 Glaser, N.S.
YR 2010
UL http://www.ajnr.org/content/31/4/780.abstract
AB SUMMARY: Recent data suggest that DKA may contribute to cognitive impairment in children with type 1 DM. We measured the NAA/Cr ratio in a teenager during and following 2 separate episodes of DKA without clinically apparent cerebral edema. The NAA/Cr ratio decreased during DKA and improved following recovery. However, the NAA/Cr value was lower after the second episode of DKA (1.76) than after the first (1.97). These findings provide support for the hypothesis that neuronal injury may result from DKA. BUNblood urea nitrogenCrcreatineDKAdiabetic ketoacidosisDMdiabetes mellitusNAAN-acetylaspartate