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PT  - JOURNAL ARTICLE
AU  - Seo, M.
AU  - Ahn, K.-J.
AU  - Choi, Y.
AU  - Shin, N.-Y.
AU  - Jang, J.
AU  - Kim, B.-S.
TI  - Volumetric Measurement of Relative CBV Using T1-Perfusion-Weighted MRI with High Temporal Resolution Compared with Traditional T2*-Perfusion-Weighted MRI in Postoperative Patients with High-Grade Gliomas
AID  - 10.3174/ajnr.A7527
DP  - 2022 Jun 01
TA  - American Journal of Neuroradiology
PG  - 864--871
VI  - 43
IP  - 6
4099  - http://www.ajnr.org/content/43/6/864.short
4100  - http://www.ajnr.org/content/43/6/864.full
SO  - Am. J. Neuroradiol.2022 Jun 01; 43
AB  - BACKGROUND AND PURPOSE: T1-PWI with high temporal resolution may provide a reliable relative CBV value as a valid alternative to T2*-PWI under increased susceptibility. The purpose of this study was to assess the technical and clinical performance of T1-relative CBV in patients with postoperative high-grade gliomas.MATERIALS AND METHODS: Forty-five MRIs of 34 patients with proved high-grade gliomas were included. In all MRIs, T1- and T2*-PWIs were both acquired and processed semiautomatically to generate relative CBV maps using a released commercial software. Lesion masks were overlaid on the relative CBV maps, followed by a histogram of the whole VOI. The intraclass correlation coefficient and Bland-Altman plots were used for quantitative and qualitative comparisons. Signal loss from both methods was compared using the Wilcoxon signed-rank test of zero voxel percentage. The MRIs were divided into a progression group (n = 20) and a nonprogression group (n = 14) for receiver operating characteristic curve analysis.RESULTS: Fair intertechnique consistency was observed between the 90th percentiles of the T1- and T2*-relative CBV values (intraclass correlation coefficient = 0.558, P &amp;lt; .001). T2*-PWI revealed a significantly higher percentage of near-zero voxels than T1-PWI (17.7% versus 3.1%, P &amp;lt; .001). There was no statistically significant difference between the area under the curve of T1- and T2*-relative CBV (0.811 versus 0.793, P = .835). T1-relative CBV showed 100% sensitivity and 57.1% specificity for the detection of progressive lesions.CONCLUSIONS: T1-relative CBV demonstrated exquisite diagnostic performance for detecting progressive lesions in postoperative patients with high-grade gliomas, suggesting the potential role of T1-PWI as a valid alternative to the traditional T2*-PWI.AUCarea under the curveCEcontrast-enhancedICCintraclass correlation coefficientrCBVrelative CBVROCreceiver operating characteristicSSEsubstantial susceptibility effectsT1-rCBVT1-PWI–derived relative CBVT2*-rCBVT2*-PWI–derived relative CBV