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RT Journal Article
SR Electronic
T1 Cerebral White Matter Lesions May Be Partially Reversible in Patients with Carotid Artery Stenosis
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 1350
OP 1352
DO 10.3174/ajnr.A1873
VO 31
IS 7
A1 Yamada, K.
A1 Sakai, K.
A1 Owada, K.
A1 Mineura, K.
A1 Nishimura, T.
YR 2010
UL http://www.ajnr.org/content/31/7/1350.abstract
AB SUMMARY: Contrary to the common belief that age-related WMLs (also known as leukoaraiosis) are a progressive condition, a case of partial reversal of WMLs shortly after carotid artery stenting is described. A 75-year-old man presented with frequent TIAs, which were attributed to right ICA stenosis. He subsequently underwent successful carotid artery stenting. Follow-up MR imaging a week after the procedure showed improvement of WMLs in the right cerebral hemisphere. Pixel-by-pixel image analysis showed that the reversed WMLs tended to have higher λ1 and lower signal intensity on b = 0 images compared with nonreversed lesions, but by only approximately 10%. ADCapparent diffusion coefficientBBBblood-brain barrierICAinternal carotid arteryDTIdiffusion tensor imagingDWIdiffusion-weighted imagingFLAIRfluid-attenuated inversion recoveryλ1axial diffusivityλ2 and λ3radial diffusivityMTTmean transit timeprebeforepostafterrCBFregional cerebral blood flowrCBVregional cerebral blood volumeTIAtransient ischemic attacksWMLwhite matter lesion