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Baseline characteristics of the population and univariate relationships with collateral gradea
Whole Cohort (n = 209)Good Collaterals (Grades 3 and 4) (n = 133)Poor Collaterals (Grades 1 and 2) (n = 76)P Value
Patient characteristics
 Age (yr)72 (61–80)72 (61–81)71 (60–80).39
 Men118 (56)73 (55)45 (59).54
 Hypertension118 (56)80 (60)38 (50).16
 Diabetes mellitus32 (15)23 (17)9 (12).29
 Current smoking26 (12)15 (11)11 (14).50
Pre-IVT characteristics
 NIHSS score16 (9–19.5)14 (7–18)17 (14–21)<.001
 Onset-to-IVT time (min)160 (130–193.5)158 (127–195)161 (135–186).67
Pre-IVT MRI
 Onset-to-MRI time (min)123 (96–154)122 (94–159)124 (101–154).74
 Occlusion site.26
  ICA-T/L36 (17)22 (17)14 (18)
  M1124 (60)75 (56)49 (65)
  M249 (23)36 (27)13 (17)
 DWI volume (mL)12 (5–25)8 (2–13)33 (16–54)<.001
 PWI volumes (mL)
  Tmax > 4 s133 (83–187)119 (70–168)176 (114–209)<.001
  Tmax > 6 s83 (44–127)64 (35–108)119 (71–166)<.001
  Tmax > 10 s31 (13–63)18 (8–44)61 (34–95)<.001
 HIR0.43 (0.30–0.53)0.36 (0.22–0.45)0.53 (0.46–0.62)<.001
 PWI-DWI mismatch profile186 (91%)127 (96%)59 (81%)<.001
 Mismatch ratio5.6 (3.0–11.1)8.2 (4.4–18.7)3.2 (2.0–5.0).001
 FVH-DWI mismatchASPECTS3 (2–5)4 (3–5)2 (0–2.75)<.001
 FVHASPECTS5 (4–5)5 (4–5.5)5 (4–5).76
  • Note:—HIR indicates Tmax > 10-second/Tmax > 6-second volume; ICA-T/L, ICA T or L occlusion; Mismatch ratio, Tmax > 6-second volume/DWI volume; PWI-DWI mismatch profile, Tmax > 6-second volume >1.8 × DWI volume.
  • ↵a Categoric variables are expressed as number (%), and continuous variables, as median (IQR). Four patients had missing PWI volume data (1 patient with good collaterals and 3 patients with poor collaterals).