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Table 2: Subgroup comparisons between treatment groups in longitudinal ΔMCS
Default Mode Network ASLN
Standard Group Intensive Group Effect Size (Cohen d) t P Value Effect Size (Cohen d) t P Value
Overall 180 226 –0.12 –1.17 .24 –0.24 –2.46 .014^{^a}
Subgroups 
 High baseline WMH 94 108 –0.14 –0.97 .33 –0.28 –2.03 .044^{^b}
 Low baseline WMH 85 118 –0.09 –0.66 .51 –0.21 –1.47 .144
 High ΔWMH 101 96 –0.08 –0.55 .59 –0.24 –1.67 .097
 Low ΔWMH 77 127 –0.12 –0.86 .39 –0.27 –1.86 .064
 Older age 97 131 –0.12 –0.90 .37 –0.28 –2.10 .037^{^b}
 Younger age 83 95 –0.11 –0.73 .47 –0.19 –.28 .20
 Larger rTBV decline 87 117 –0.32 –2.27 .024^{^b} –0.09 –0.64 .52
 Smaller rTBV decline 93 109 0.09 0.66 .51 –0.39 –2.79 .0058^{^b}
↵a P <. 05, Bonferroni-corrected.
↵b P <. 05, uncorrected.

			Default Mode Network			ASLN
	Standard Group	Intensive Group	Effect Size (Cohen d)	t	P Value	Effect Size (Cohen d)	t	P Value
Overall	180	226	–0.12	–1.17	.24	–0.24	–2.46	.014^{^a}
Subgroups
High baseline WMH	94	108	–0.14	–0.97	.33	–0.28	–2.03	.044^{^b}
Low baseline WMH	85	118	–0.09	–0.66	.51	–0.21	–1.47	.144
High ΔWMH	101	96	–0.08	–0.55	.59	–0.24	–1.67	.097
Low ΔWMH	77	127	–0.12	–0.86	.39	–0.27	–1.86	.064
Older age	97	131	–0.12	–0.90	.37	–0.28	–2.10	.037^{^b}
Younger age	83	95	–0.11	–0.73	.47	–0.19	–.28	.20
Larger rTBV decline	87	117	–0.32	–2.27	.024^{^b}	–0.09	–0.64	.52
Smaller rTBV decline	93	109	0.09	0.66	.51	–0.39	–2.79	.0058^{^b}