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Table 3: Association of measures of continuous imaging features with variant histone H3–altered versus H3 wild-type tumors
Imaging Metric Any Histone Mutation Wild-Type P Value^{^a}
No. Median (Range) No. Median (Range)
ADC total (×10^–6 mm²/s) 
 Mean 61 1302.42 (538.06–1797.58) 12 1350.77 (922.96–1729.62) .98
 Median 61 1245 (532–1842) 12 1345 (917–1781) .97
 Mode 61 1250.51 (450.92–1961.24) 12 1305.29 (863.39–1805.47) .9
 Skewness 52 0.68 (−0.89–3.11) 11 0.98 (−0.30–2.57) .3
 Kurtosis 52 1.4 (−0.78–15.62) 11 2.82 (−0.78–10.77) .1
ADC_enhancement (×10^–6 mm²/s) 
 Mean 45 1152.88 (689.44–1898.26) 6 1199.86 (956.62–1723.18) .7
 Median 45 1142.00 (667–1890) 6 1187.00 (807–1762) .7
 Mode 45 1062.49 (577.86–1746.86) 6 1175.10 (719.70–1805.78) .6
 Skewness 43 0.86 (−0.85–4.73) 6 0.67 (−0.14–1.86) .7
 Kurtosis 43 1.69 (−0.94–29.06) 6 1.35 (0.098–12.45) .9
FLAIR/T2/T1 PG volume (×10³ mm³) 
 FLAIR/T2 60 35.13 (7.97–77.57) 13 32.77 (10.13–79.62) .8
 Enhancing 46 1.96 (0.04–14.10) 8 1.95 (0.01–4.71) .4
↵a Wilcoxon rank-sum test.

Imaging Metric	Any Histone Mutation		Wild-Type		P Value^{^a}
Imaging Metric	No.	Median (Range)	No.	Median (Range)	P Value^{^a}
ADC total (×10^–6 mm²/s)
Mean	61	1302.42 (538.06–1797.58)	12	1350.77 (922.96–1729.62)	.98
Median	61	1245 (532–1842)	12	1345 (917–1781)	.97
Mode	61	1250.51 (450.92–1961.24)	12	1305.29 (863.39–1805.47)	.9
Skewness	52	0.68 (−0.89–3.11)	11	0.98 (−0.30–2.57)	.3
Kurtosis	52	1.4 (−0.78–15.62)	11	2.82 (−0.78–10.77)	.1
ADC_enhancement (×10^–6 mm²/s)
Mean	45	1152.88 (689.44–1898.26)	6	1199.86 (956.62–1723.18)	.7
Median	45	1142.00 (667–1890)	6	1187.00 (807–1762)	.7
Mode	45	1062.49 (577.86–1746.86)	6	1175.10 (719.70–1805.78)	.6
Skewness	43	0.86 (−0.85–4.73)	6	0.67 (−0.14–1.86)	.7
Kurtosis	43	1.69 (−0.94–29.06)	6	1.35 (0.098–12.45)	.9
FLAIR/T2/T1 PG volume (×10³ mm³)
FLAIR/T2	60	35.13 (7.97–77.57)	13	32.77 (10.13–79.62)	.8
Enhancing	46	1.96 (0.04–14.10)	8	1.95 (0.01–4.71)	.4