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Table 2: Association of measures of continuous imaging features with variant histone H3–altered tumors
Imaging Metric H3-3A H3C2/3 P Value^{^a}
No. Median (Range) No. Median (Range)
ADC total (×10^–6 mm²/s) 
 Mean 46 1227.51 (538.06–1710.88) 9 1586.56 (1224.37–1797.58) .001
 Median 46 1185 (532–1755) 9 1654 (1215–1842) .001
 Mode 46 1168.14 (450.92–1902.53) 9 1703.88 (1263.52–1961.24) .001
 Skewness 38 0.91 (−0.49–2.16) 9 –0.20 (−0.89–0.88) .003
 Kurtosis 38 1.57 (−0.60–9.71) 9 0.40 (−0.78–1.79) .002
ADC_enhancement (×10^–6 mm²/s) 
 Mean 33 1138.81 (689.44–1509.96) 7 1390.54 (1033.58–1898.26) .004
 Median 33 1085 (667–1532) 7 1364 (995–1890) .003
 Mode 33 1012.56 (577.86–1617.56) 7 1393.38 (966.31–1746.86) .002
 Skewness 31 1.27 (−0.56–2.82) 7 0.52 (−0.71–2.61) .1
 Kurtosis 31 2.08 (−0.94–13.03) 7 0.85 (−0.84–9.09) .3
FLAIR/T2/T1 PG volume (×10³ mm³) 
 FLAIR/T2 44 35.75 (7.97–77.53) 10 41.10 (22.84–77.57) .2
 Enhancing 32 1.90 (0.07–14.10) 9 5.04 (0.04–8.25) .6
↵a Wilcoxon rank-sum test.