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Table 1: Patient characteristics and WML scores
All Men Women
Patient characteristics 
 No. of patients (%) 48 25 (52%) 23 (48%)
 Classic phenotype (No.) (%) 48 (100%) 25 (100%) 23 (100%)
 No. of scan data sets (No.) 229 117 112
 Age at first MR imaging (median) (range) (yr) 44 (15–69) 31 (15–55) 46 (22–69)
 Patients <18 yr (No.) (%) 2 (4.2%) 2 (8.0%) 0 (0.0%)
 Ever ERT (No.) (%) 48 (100%) 25 (100%) 23 (100%)
 Months treated (mean) 89 (SD, 34) 92 (SD, 39) 86 (SD, 30)
Events before first MR imaging 
 Cerebrovascular event (No.) (%) 2 (4.2%) 1 (4.0%) 1 (4.3%)
 TIA (No.) (%) 1 (2.1%) 1 (4.0%) 0 (0.0%)
Kidney function at first MR imaging 
 eGFR in mL/min/1.73 m² (median) (range) 101 (40–154) 105 (49–154) 100 (40–127)
 eGFR <60 mL/min/1.73 m² (No.) (%) 5 (10.4%) 3 (12%) 2 (8.7%)
WML scores 
 Fazekas first MR imaging (median) (range) 1 (0–6) 0 (0–6) 1 (0–6)
 Fazekas first MR imaging (mean) 1.5 (SD, 1.7) 1.4 (SD, 2.0) 1.5 (SD, 1.3)
 Fazekas > 0 first MR imaging (No.) (%) 29 (60%) 11 (44%) 18 (78%)
 Fazekas last MR imaging (median) (range)^{^a} 1 (0–6) 1 (0–6) 1 (0–6)
 Fazekas last MR imaging (mean) 1.5 (SD, 1.6) 1.6 (SD, 1.9) 1.4 (SD, 1.3)
 Fazekas > 0 last MR imaging (No.) (%) 33 (69%) 15 (60%) 18 (78%)
Note:—eGFR indicates estimated glomerular filtration rate.
↵a For 32 patients, additional MR imaging after Fazekas scoring was performed. For these patients, the last known Fazekas score was used.