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Demographic details of the study population
MS Clinical ProfilesAll Patients with MSHC SubgroupsT Test (W)a/χ2 Test (C2)b
CISRRMSPMSCamCAN (External)TUM (Internal)T Test (W)/χ2 Test (C2) between HC
No. subjects194651750165189NANA
Age (mean) (yr)58.73 (SD, 12.06)40.14 (SD, 9.94)55.58 (SD, 5.23)40.56 (SD, 10.22)54.26 (SD, 18.58)37.36 (SD, 15.06)W: t (150.61) = 9.78, P < .001W: t (102.87) = −1.92, P = .056
Sex (female/male)13:6305:16010:7328:173330:32159:30C2: χ2 (1, N = 740) = 7.03, P = .008C2: χ2 (1, N= 590) < 0.001, P = .976
Dominant hand (R/L)19/0415/5016/1450/51NANANANA
EDSS (median) (IQR)0.0 (1.0)1.5 (2.0)4.25 (1.75)1.5 (2.0)NANANANA
Cognition MuSIC (mean)28.05 (SD, 3.01)27.10 (SD, 3.66)25.82 (SD, 4.05)27.09 (SD, 3.66)NANANANA
Fatigue MuSIC (mean)6.21 (SD, 2.64)7.58 (SD, 4.59)11.65 (SD, 3.32)7.67 (SD, 4.56)NANANANA
Lesion volume, (mean) (mL)0.98 (SD, 1.23)5.39 (SD, 8.41)11.78 (SD, 9.01)5.45 (SD, 8.40)NANANANA
  • Note:—R indicates right; L, left.
  • ↵a Welch 2-sample t tests were performed to test differences in age between all patients with MS versus TUM (ie, internal) HC.
  • ↵b χ2 tests were performed to test differences in sex frequencies between all patients with MS versus TUM (ie, internal) HC.