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Table 2: Characteristics and results of the cases with astrocytoma, IDH-mutant, CNS WHO grades 2–4
Case Age (yr) Subgroup Fusion/Methylation Analysis T2-FLAIR Mismatch Sign (S) or Area (A) Histology
Microcysts Enlarged Intercellular Spaces
12 17.7 IDH +, WHO 2 IDH (R132H), ATRX, TP53 + (A) + +
13 9.2 IDH +, WHO 2 IDH (R132H), TP53 – + +
14 18.7 IDH +, WHO 2 IDH (R132H), ATRX, TP53 + (S) – +
15 14.0 IDH +, WHO 2 IDH (R132H), ATRX, TP53 – + +
16 10.6 IDH +, WHO 2 IDH (R132H), TP53 – – +
17 4.0 IDH +, WHO 2 IDH (R132H), PIK3CA, NF1 – + –
18 17.1 IDH +, WHO 3 IDH (R132H), PTEN, TP53 – + +
19 15.6 IDH +, WHO 4 IDH (R132H), TP53, MSH6, ATRX, CDKN2A, CIC. – 
Note:—The + indicates presence; −, absence of the characteristic.

Case	Age (yr)	Subgroup	Fusion/Methylation Analysis	T2-FLAIR Mismatch Sign (S) or Area (A)	Histology
Case	Age (yr)	Subgroup	Fusion/Methylation Analysis	T2-FLAIR Mismatch Sign (S) or Area (A)	Microcysts	Enlarged Intercellular Spaces
12	17.7	IDH +, WHO 2	IDH (R132H), ATRX, TP53	+ (A)	+	+
13	9.2	IDH +, WHO 2	IDH (R132H), TP53	–	+	+
14	18.7	IDH +, WHO 2	IDH (R132H), ATRX, TP53	+ (S)	–	+
15	14.0	IDH +, WHO 2	IDH (R132H), ATRX, TP53	–	+	+
16	10.6	IDH +, WHO 2	IDH (R132H), TP53	–	–	+
17	4.0	IDH +, WHO 2	IDH (R132H), PIK3CA, NF1	–	+	–
18	17.1	IDH +, WHO 3	IDH (R132H), PTEN, TP53	–	+	+
19	15.6	IDH +, WHO 4	IDH (R132H), TP53, MSH6, ATRX, CDKN2A, CIC.	–